Nature Communications (Dec 2017)
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism
- Junpei Yamamoto,
- Junta Imai,
- Tomohito Izumi,
- Hironori Takahashi,
- Yohei Kawana,
- Kei Takahashi,
- Shinjiro Kodama,
- Keizo Kaneko,
- Junhong Gao,
- Kenji Uno,
- Shojiro Sawada,
- Tomoichiro Asano,
- Vladimir V. Kalinichenko,
- Etsuo A. Susaki,
- Makoto Kanzaki,
- Hiroki R. Ueda,
- Yasushi Ishigaki,
- Tetsuya Yamada,
- Hideki Katagiri
Affiliations
- Junpei Yamamoto
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Junta Imai
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Tomohito Izumi
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Hironori Takahashi
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Yohei Kawana
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Kei Takahashi
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Shinjiro Kodama
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Keizo Kaneko
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Junhong Gao
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Kenji Uno
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Shojiro Sawada
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Tomoichiro Asano
- Department of Medical Science, Graduate School of Medicine, University of Hiroshima
- Vladimir V. Kalinichenko
- Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center
- Etsuo A. Susaki
- Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo
- Makoto Kanzaki
- Tohoku University Graduate School of Biomedical Engineering
- Hiroki R. Ueda
- Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo
- Yasushi Ishigaki
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Tetsuya Yamada
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- Hideki Katagiri
- Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-01869-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Neuronal signals, in particular those transmitted via the vagal nerve, regulate both β-cell function and proliferation. Here, Yamamoto et al. show that the forkhead box M1 pathway is required for vagal signal-mediated induction of β-cell proliferation during obesity.
