Acetylene in Organic Synthesis: Recent Progress and New Uses

Abstract

Recent progress in the leading synthetic applications of acetylene is discussed from the prospect of rapid development and novel opportunities. A diversity of reactions involving the acetylene molecule to carry out vinylation processes, cross-coupling reactions, synthesis of substituted alkynes, preparation of heterocycles and the construction of a number of functionalized molecules with different levels of molecular complexity were recently studied. Of particular importance is the utilization of acetylene in the synthesis of pharmaceutical substances and drugs. The increasing interest in acetylene and its involvement in organic transformations highlights a fascinating renaissance of this simplest alkyne molecule.

Keywords

• acetylene
• vinylation
• cross-coupling
• addition reactions
• drugs
• pharmaceutical substances
• biologically active molecule
• monomers
• polymers