Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Md Habibur Rahman; Anup Bhusal; Jae-Hong Kim; Mithilesh Kumar Jha; Gyun Jee Song; Younghoon Go; Il-Sung Jang; In-Kyu Lee; Kyoungho Suk

doi:10.1038/s41467-020-19576-1

Nature Communications (Nov 2020)

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Md Habibur Rahman,
Anup Bhusal,
Jae-Hong Kim,
Mithilesh Kumar Jha,
Gyun Jee Song,
Younghoon Go,
Il-Sung Jang,
In-Kyu Lee,
Kyoungho Suk

Affiliations

Md Habibur Rahman: BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National University
Anup Bhusal: BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National University
Jae-Hong Kim: BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National University
Mithilesh Kumar Jha: Department of Neurology, Johns Hopkins University
Gyun Jee Song: Department of Medical Science, College of Medicine, Catholic Kwandong University
Younghoon Go: Korean Medicine Application Center, Korea Institute of Oriental Medicine
Il-Sung Jang: Department of Pharmacology, School of Dentistry, Kyungpook National University
In-Kyu Lee: Department of Internal Medicine, School of Medicine, Kyungpook National University Hospital
Kyoungho Suk: BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science and Department of Pharmacology, School of Medicine, Kyungpook National University

DOI: https://doi.org/10.1038/s41467-020-19576-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 20

Abstract

Read online

Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal