Nature Communications (Oct 2022)
Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis
- Carmen Aguilar,
- Mindaugas Pauzuolis,
- Malvika Pompaiah,
- Ehsan Vafadarnejad,
- Panagiota Arampatzi,
- Mara Fischer,
- Dominik Narres,
- Mastura Neyazi,
- Özge Kayisoglu,
- Thomas Sell,
- Nils Blüthgen,
- Markus Morkel,
- Armin Wiegering,
- Christoph-Thomas Germer,
- Stefan Kircher,
- Andreas Rosenwald,
- Antoine-Emmanuel Saliba,
- Sina Bartfeld
Affiliations
- Carmen Aguilar
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Mindaugas Pauzuolis
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Malvika Pompaiah
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Ehsan Vafadarnejad
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI)
- Panagiota Arampatzi
- Core Unit Systems Medicine, University of Würzburg
- Mara Fischer
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Dominik Narres
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Mastura Neyazi
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Özge Kayisoglu
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- Thomas Sell
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Nils Blüthgen
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Markus Morkel
- Institute of Pathology, Charité Universitätsmedizin Berlin
- Armin Wiegering
- Department of General, Visceral, Vascular and Paediatric Surgery, University Hospital of Würzburg
- Christoph-Thomas Germer
- Department of General, Visceral, Vascular and Paediatric Surgery, University Hospital of Würzburg
- Stefan Kircher
- Institute of Pathology, Julius Maximilian University of Würzburg and Comprehensive Cancer Center Mainfranken
- Andreas Rosenwald
- Institute of Pathology, Julius Maximilian University of Würzburg and Comprehensive Cancer Center Mainfranken
- Antoine-Emmanuel Saliba
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI)
- Sina Bartfeld
- Research Centre for Infectious Diseases, Institute for Molecular Infection Biology, Julius Maximilians University of Würzburg
- DOI
- https://doi.org/10.1038/s41467-022-33165-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The carcinogenic bacterium Helicobacter pylori infects gastric cells. Here, the authors show that H. pylori preferentially infects differentiated cells in the pit region of gastric units, and this relies on bacterial chemotaxis towards host cell-released urea, which scales with host cell size.
