Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Jan 2020)

Dual sensory impairment in older adults and risk of dementia from the GEM Study

  • Phillip H. Hwang,
  • W.T. Longstreth Jr,
  • Willa D. Brenowitz,
  • Stephen M. Thielke,
  • Oscar L. Lopez,
  • Courtney E. Francis,
  • Steven T. DeKosky,
  • Annette L. Fitzpatrick

DOI
https://doi.org/10.1002/dad2.12054
Journal volume & issue
Vol. 12, no. 1
pp. n/a – n/a

Abstract

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Abstract Introduction Hearing and vision loss are independently associated with dementia, but the impact of dual sensory impairment (DSI) on dementia risk is not well understood. Methods Self‐reported measures of hearing and vision were taken from 2051 participants at baseline from the Gingko Evaluation of Memory Study. Dementia status was ascertained using standardized criteria. Cox models were used to estimate risk of dementia associated with number of sensory impairments (none, one, or two). Results DSI was significantly associated with higher risk of all‐cause dementia (hazard ratio [HR] = 1.86; 95% confidence interval [CI] = 1.25‐2.76) and Alzheimer's disease (HR = 2.12; 95% CI = 1.34‐3.36). Individually only visual impairment was independently associated with an increased risk of all‐cause dementia (HR = 1.32; 95% CI = 1.02‐1.71). Discussion Older adults with DSI are at a significantly increased risk for dementia. Further studies are needed to evaluate whether treatments can modify this risk.

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