Cross-species oncogenic signatures of breast cancer in canine mammary tumors

Tae-Min Kim; In Seok Yang; Byung-Joon Seung; Sejoon Lee; Dohyun Kim; Yoo-Jin Ha; Mi-kyoung Seo; Ka-Kyung Kim; Hyun Seok Kim; Jae-Ho Cheong; Jung-Hyang Sur; Hojung Nam; Sangwoo Kim

doi:10.1038/s41467-020-17458-0

Nature Communications (Jul 2020)

Cross-species oncogenic signatures of breast cancer in canine mammary tumors

Tae-Min Kim,
In Seok Yang,
Byung-Joon Seung,
Sejoon Lee,
Dohyun Kim,
Yoo-Jin Ha,
Mi-kyoung Seo,
Ka-Kyung Kim,
Hyun Seok Kim,
Jae-Ho Cheong,
Jung-Hyang Sur,
Hojung Nam,
Sangwoo Kim

Affiliations

Tae-Min Kim: Department of Medical Informatics and Cancer Research Institute, College of Medicine, The Catholic University of Korea
In Seok Yang: Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine
Byung-Joon Seung: Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University
Sejoon Lee: Department of Pathology and Translational Medicine, Seoul National University Bundang Hospital
Dohyun Kim: School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology (GIST)
Yoo-Jin Ha: Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine
Mi-kyoung Seo: Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine
Ka-Kyung Kim: Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine
Hyun Seok Kim: Severance Biomedical Science Institute, Yonsei University College of Medicine
Jae-Ho Cheong: Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine
Jung-Hyang Sur: Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University
Hojung Nam: School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology (GIST)
Sangwoo Kim: Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine

DOI: https://doi.org/10.1038/s41467-020-17458-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Comparison of spontaneous canine cancers and human cancers may illuminate future therapeutic avenues. Here, genomic analyses of these tumors highlights a convergence on PI3K-Akt oncogenic pathways.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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