The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

Junpei Suzuki; Takeshi Yamada; Kazuki Inoue; Shogo Nabe; Makoto Kuwahara; Nobuaki Takemori; Ayako Takemori; Seiji Matsuda; Makoto Kanoh; Yuuki Imai; Masaki Yasukawa; Masakatsu Yamashita

doi:10.1038/s41467-018-05854-6

Nature Communications (Aug 2018)

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

Junpei Suzuki,
Takeshi Yamada,
Kazuki Inoue,
Shogo Nabe,
Makoto Kuwahara,
Nobuaki Takemori,
Ayako Takemori,
Seiji Matsuda,
Makoto Kanoh,
Yuuki Imai,
Masaki Yasukawa,
Masakatsu Yamashita

Affiliations

Junpei Suzuki: Department of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University, Shitsukawa
Takeshi Yamada: Department of Infections and Host Defenses, Graduate School of Medicine, Ehime University, Shitsukawa
Kazuki Inoue: Division of Integrative Pathophysiology, Department of Proteo-Inovation, Proteo-Science Center, Ehime University
Shogo Nabe: Department of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University, Shitsukawa
Makoto Kuwahara: Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa
Nobuaki Takemori: Division of Proteomics Research, Department of Proteo-Medicine, Proteo-Science Center, Ehime University
Ayako Takemori: Division of Proteomics Research, Department of Proteo-Medicine, Proteo-Science Center, Ehime University
Seiji Matsuda: Department of Anatomy and Embryology, Graduate School of Medicine, Ehime University, Shitsukawa
Makoto Kanoh: Department of Infections and Host Defenses, Graduate School of Medicine, Ehime University, Shitsukawa
Yuuki Imai: Division of Integrative Pathophysiology, Department of Proteo-Inovation, Proteo-Science Center, Ehime University
Masaki Yasukawa: Department of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University, Shitsukawa
Masakatsu Yamashita: Department of Immunology, Graduate School of Medicine, Ehime University, Shitsukawa

DOI: https://doi.org/10.1038/s41467-018-05854-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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