Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Dec 2021)

Association of Region‐Specific Cardiac Adiposity With Dysglycemia and New‐Onset Diabetes

  • Kuo‐Tzu Sung,
  • Jen‐Yuan Kuo,
  • Chun‐Ho Yun,
  • Yueh‐Hung Lin,
  • Jui‐Peng Tsai,
  • Chi‐In Lo,
  • Chih‐Chung Hsiao,
  • Yau‐Huei Lai,
  • Cheng‐Ting Tsai,
  • Charles Jia‐Yin Hou,
  • Cheng‐Huang Su,
  • Hung‐I Yeh,
  • Chen‐Yen Chien,
  • Ta‐Chuan Hung,
  • Chung‐Lieh Hung

DOI
https://doi.org/10.1161/JAHA.121.021921
Journal volume & issue
Vol. 10, no. 24

Abstract

Read online

Background Visceral adipose tissue is assumed to be an important indicator for insulin resistance and diabetes beyond overweight/obesity. We hypothesized that region‐specific visceral adipose tissue may regulate differential biological effects for new‐onset diabetes regardless of overall obesity. Methods and Results We quantified various visceral adipose tissue measures, including epicardial adipose tissue, paracardial adipose tissue, interatrial fat, periaortic fat, and thoracic aortic adipose tissue in 1039 consecutive asymptomatic participants who underwent multidetector computed tomography. We explored the associations of visceral adipose tissue with baseline dysglycemic indices and new‐onset diabetes. Epicardial adipose tissue, paracardial adipose tissue, interatrial fat, periaortic fat, and thoracic aortic adipose tissue were differentially and independently associated with dysglycemic indices (fasting glucose, postprandial glucose, HbA1c, and homeostasis model assessment of insulin resistance) beyond anthropometric measures. The superimposition of interatrial fat and thoracic aortic adipose tissue on age, sex, body mass index, and baseline homeostasis model assessment of insulin resistance expanded the likelihood of baseline diabetes (from 67.2 to 86.0 and 64.4 to 70.8, P for ∆ ꭕ2: <0.001 and 0.011, respectively). Compared with the first tertile, the highest interatrial fat tertile showed a nearly doubled risk for new‐onset diabetes (hazard ratio, 2.09 [95% CI, 1.38–3.15], P<0.001) after adjusting for Chinese Visceral Adiposity Index. Conclusions Region‐specific visceral adiposity may not perform equally in discriminating baseline dysglycemia or diabetes, and showed differential predictive performance in new‐onset diabetes. Our data suggested that interatrial fat may serve as a potential marker for new‐onset diabetes.

Keywords