Nature Communications (May 2018)

Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

  • Masayoshi Ohkuro,
  • Jun-Dal Kim,
  • Yoshikazu Kuboi,
  • Yuki Hayashi,
  • Hayase Mizukami,
  • Hiroko Kobayashi-Kuramochi,
  • Kenzo Muramoto,
  • Manabu Shirato,
  • Fumiko Michikawa-Tanaka,
  • Jun Moriya,
  • Teruya Kozaki,
  • Kazuma Takase,
  • Kenichi Chiba,
  • Kishan Lal Agarwala,
  • Takayuki Kimura,
  • Makoto Kotake,
  • Tetsuya Kawahara,
  • Naoki Yoneda,
  • Shinsuke Hirota,
  • Hiroshi Azuma,
  • Nobuko Ozasa-Komura,
  • Yoshiaki Ohashi,
  • Masafumi Muratani,
  • Keiji Kimura,
  • Ieharu Hishinuma,
  • Akiyoshi Fukamizu

DOI
https://doi.org/10.1038/s41467-018-04420-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the severity of IBD in animal models.