Diagnóstico de warfarina en muestras remitidas al CIESA durante el período 2015-2018. Una problemática recurrente

Abstract

The objective of this work was to determine the number of diagnosed cases of warfarin, used to control or combat "pests" (rodents), in order to highlight the importance of the proper use and application of this substance at the agricultural and even domestic level. There was a total of 21 samples, which corresponded to: Liver, gastric content, and prepared baits, sent to the Toxicology area of the Center for Research and Advanced Studies in Animal Health (CEISA), in the period 2015-2018, the determination of warfarin was carried out through thin layer chromatography, and the descriptive method was used to report the results. The percentage of positivity to warfarin in the study period was 71.41 %. The largest number of samples were livers (14 samples), of which 10 (47.61 %) were positive; followed by gastric content with 3 positives (14.28 %), and prepared baits (pieces of chicken meat, sausages, and ham) with 2 (9.52 %). In the applications per year, in 2017 and 2018 they increased, with 6 and 9 cases, of which 5 and 7 were positive for warfarin (23.81 and 33.33 %), respectively, 3 samples (livers) were collected and sent from the autopsy area of CIESA, where evidence of lesions suggestive of warfarin intoxication was shown. Under the conditions of occurrence and presentation of cases of warfarin poisoning, it is necessary to regulate the commercialization not only of rodenticides, but of all agricultural products that are currently commercialized, to minimize the risk of poisoning in the different animal species and even to avoid the harmful effect on public health and the environment.

Keywords

• rodenticide
• warfarin
• poisoning
• dog
• thin layer chromatography.