Nature Communications (Sep 2022)
Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis
- Derek W. Brown,
- Weiyin Zhou,
- Youjin Wang,
- Kristine Jones,
- Wen Luo,
- Casey Dagnall,
- Kedest Teshome,
- Alyssa Klein,
- Tongwu Zhang,
- Shu-Hong Lin,
- Olivia W. Lee,
- Sairah Khan,
- Jacqueline B. Vo,
- Amy Hutchinson,
- Jia Liu,
- Jiahui Wang,
- Bin Zhu,
- Belynda Hicks,
- Andrew St. Martin,
- Stephen R. Spellman,
- Tao Wang,
- H. Joachim Deeg,
- Vikas Gupta,
- Stephanie J. Lee,
- Neal D. Freedman,
- Meredith Yeager,
- Stephen J. Chanock,
- Sharon A. Savage,
- Wael Saber,
- Shahinaz M. Gadalla,
- Mitchell J. Machiela
Affiliations
- Derek W. Brown
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Weiyin Zhou
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Youjin Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kristine Jones
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Wen Luo
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Casey Dagnall
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kedest Teshome
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Alyssa Klein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Tongwu Zhang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Shu-Hong Lin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Olivia W. Lee
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sairah Khan
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jacqueline B. Vo
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Amy Hutchinson
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jia Liu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jiahui Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Bin Zhu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Belynda Hicks
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Andrew St. Martin
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin
- Stephen R. Spellman
- Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
- Tao Wang
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin
- H. Joachim Deeg
- Clinical Research Division, Fred Hutchinson Cancer Research Center
- Vikas Gupta
- MPN Program, Princess Margaret Cancer Centre, University of Toronto
- Stephanie J. Lee
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin
- Neal D. Freedman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sharon A. Savage
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Wael Saber
- Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin
- Shahinaz M. Gadalla
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Mitchell J. Machiela
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-022-32986-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Myelofibrosis is a risk factor for the development of Acute Myeloid Leukaemia. Here, the authors carry out an integrated genomic investigation of 933 myelofibrosis patients, and identified interactions between germline and somatic variation in patients who required haematopoietic cell transplantation.
