Nature Communications (Nov 2020)
Transient commensal clonal interactions can drive tumor metastasis
- Suha Naffar-Abu Amara,
- Hendrik J. Kuiken,
- Laura M. Selfors,
- Timothy Butler,
- Marco L. Leung,
- Cheuk T. Leung,
- Elaine P. Kuhn,
- Teodora Kolarova,
- Carina Hage,
- Kripa Ganesh,
- Richard Panayiotou,
- Rosemary Foster,
- Bo R. Rueda,
- Athena Aktipis,
- Paul Spellman,
- Tan A. Ince,
- Joanne Xiu,
- Matthew Oberley,
- Zoran Gatalica,
- Nicholas Navin,
- Gordon B. Mills,
- Rodrick T. Bronson,
- Joan S. Brugge
Affiliations
- Suha Naffar-Abu Amara
- Department of Cell Biology, Harvard Medical School
- Hendrik J. Kuiken
- Department of Cell Biology, Harvard Medical School
- Laura M. Selfors
- Department of Cell Biology, Harvard Medical School
- Timothy Butler
- Department of Molecular and Medical Genetics, Oregon Health & Science University Portland
- Marco L. Leung
- Department of Genetics, University of Texas MD Anderson Cancer Center
- Cheuk T. Leung
- Department of Cell Biology, Harvard Medical School
- Elaine P. Kuhn
- Department of Cell Biology, Harvard Medical School
- Teodora Kolarova
- Department of Cell Biology, Harvard Medical School
- Carina Hage
- Department of Cell Biology, Harvard Medical School
- Kripa Ganesh
- Department of Cell Biology, Harvard Medical School
- Richard Panayiotou
- Department of Cell Biology, Harvard Medical School
- Rosemary Foster
- Vincent Center for Reproductive Biology and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital
- Bo R. Rueda
- Vincent Center for Reproductive Biology and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital
- Athena Aktipis
- Arizona Cancer Evolution Center and Department of Psychology, Arizona State University
- Paul Spellman
- Department of Molecular and Medical Genetics, Oregon Health & Science University Portland
- Tan A. Ince
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Joanne Xiu
- Caris Life Sciences
- Matthew Oberley
- Caris Life Sciences
- Zoran Gatalica
- Caris Life Sciences
- Nicholas Navin
- Department of Genetics, University of Texas MD Anderson Cancer Center
- Gordon B. Mills
- Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University Knight Cancer Institute
- Rodrick T. Bronson
- Rodent Histopathology Core, Harvard Medical School
- Joan S. Brugge
- Department of Cell Biology, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-19584-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Cooperative interactions among tumor cells may have important implications for metastasis. Here, the authors examined the spatio-temporal nature of interactions among clonal populations of ovarian carcinoma cells and found that transient interactions cells can promote metastases via commensal interactions.
