Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system

Abstract

Degrons are determinants within proteins that direct programmed degradation by the ubiquitinproteasome system. Here, the authors propose a three-part degron architecture which contains an E3-ligase recognition motif, a ubiquitination site(s), and a disordered site to initiate degradation.