Nature Communications (Aug 2020)
Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
- Gianluca Ianiro,
- Ernesto Rossi,
- Andrew M. Thomas,
- Giovanni Schinzari,
- Luca Masucci,
- Gianluca Quaranta,
- Carlo Romano Settanni,
- Loris Riccardo Lopetuso,
- Federica Armanini,
- Aitor Blanco-Miguez,
- Francesco Asnicar,
- Clarissa Consolandi,
- Roberto Iacovelli,
- Maurizio Sanguinetti,
- Giampaolo Tortora,
- Antonio Gasbarrini,
- Nicola Segata,
- Giovanni Cammarota
Affiliations
- Gianluca Ianiro
- Digestive Disease Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Ernesto Rossi
- Medical Oncology Unit, Comprehensive Cancer Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Andrew M. Thomas
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Giovanni Schinzari
- Medical Oncology Unit, Comprehensive Cancer Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Luca Masucci
- Microbiology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Gianluca Quaranta
- Microbiology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Carlo Romano Settanni
- Digestive Disease Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Loris Riccardo Lopetuso
- Digestive Disease Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Federica Armanini
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Aitor Blanco-Miguez
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Francesco Asnicar
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Clarissa Consolandi
- Institute of Biomedical Technologies (IBT), Italian National Research Council (CNR)
- Roberto Iacovelli
- Medical Oncology Unit, Comprehensive Cancer Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Maurizio Sanguinetti
- Microbiology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Giampaolo Tortora
- Medical Oncology Unit, Comprehensive Cancer Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Antonio Gasbarrini
- Digestive Disease Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- Nicola Segata
- Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento
- Giovanni Cammarota
- Digestive Disease Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore
- DOI
- https://doi.org/10.1038/s41467-020-18127-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 6
Abstract
Tyrosine kinase inhibitors (TKIs) have improved the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC), however TKI-related diarrhoea is a common and serious adverse effect. Here the authors show in a randomized clinical trial that faecal microbiota transplantation from healthy donors can improve TKI-induced diarrhoea in patients with mRCC.
