Chromosomal Aneuploidy Affects the Global Proteome Equilibrium of Colorectal Cancer Cells

Timo Gemoll; Jens K. Habermann; Susanne Becker; Silke Szymczak; Madhvi B. Upender; Hans-Peter Bruch; Ulf Hellman; Thomas Ried; Gert Auer; Hans Jörnvall; Uwe J. Roblick

doi:10.3233/ACP-140088

Analytical Cellular Pathology (Jan 2013)

Chromosomal Aneuploidy Affects the Global Proteome Equilibrium of Colorectal Cancer Cells

Timo Gemoll,
Jens K. Habermann,
Susanne Becker,
Silke Szymczak,
Madhvi B. Upender,
Hans-Peter Bruch,
Ulf Hellman,
Thomas Ried,
Gert Auer,
Hans Jörnvall,
Uwe J. Roblick

Affiliations

Timo Gemoll: Section for Translational Surgical Oncology & Biobanking, Department of Surgery, University of Lübeck, Lübeck, Germany
Jens K. Habermann: Section for Translational Surgical Oncology & Biobanking, Department of Surgery, University of Lübeck, Lübeck, Germany
Susanne Becker: Karolinska Biomic Center, Karolinska Institutet, Stockholm, Sweden
Silke Szymczak: Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany
Madhvi B. Upender: Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
Hans-Peter Bruch: Section for Translational Surgical Oncology & Biobanking, Department of Surgery, University of Lübeck, Lübeck, Germany
Ulf Hellman: Ludwig Institute for Cancer Research, Ltd. Uppsala, Uppsala, Sweden
Thomas Ried: Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
Gert Auer: Karolinska Biomic Center, Karolinska Institutet, Stockholm, Sweden
Hans Jörnvall: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Uwe J. Roblick: Section for Translational Surgical Oncology & Biobanking, Department of Surgery, University of Lübeck, Lübeck, Germany

DOI: https://doi.org/10.3233/ACP-140088
Journal volume & issue: Vol. 36, no. 5-6
pp. 149 – 161

Abstract

Read online

Background: Chromosomal aneuploidy has been identified as a prognostic factor in the majority of sporadic carcinomas. However, it is not known how chromosomal aneuploidy affects chromosome-specific protein expression in particular, and the cellular proteome equilibrium in general.

Published in Analytical Cellular Pathology

ISSN: 2210-7177 (Print); 2210-7185 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

About the journal