The role of the local and general somatic factors for the open-angle glaucoma development in patients with eye manifestations of pseudoexfoliation syndrome

Abstract

ABSTRACT Pseudoexfoliation syndrome (PEX) is one of the best known triggers of glaucoma. The development of the open-angle glaucoma only in some patients with the PEX with definite local and general risk factors requires a further research. Purpose. The detection of the risk factors of primary open-angle glaucoma development in patients with the PEX. Material and methods. There were examined 185 patients aged 48-87 years with primary open-angle glaucoma and 75 patients of the control group. In all patients a complex eye examination was performed in addition to questionnaire and the anamnesis review. Results. In the experimental and the control groups of patients the values of the following eye parameters were assessed: length of the eye, thickness of the lens, depth of the anterior chamber, degree of PEX manifestations, nucleus density, pigmentation of the anterior chamber angle and also the presence of the concomitant vascular pathology was detected. Using the method of regression analysis a statistically significant correlation (p<0.05) was found between the open-angle glaucoma development in patients with PEX and the further parameters: age, thickness of the lens, degree of PEX manifestations, the presence of arterial hypertension, ischemic heart disease, chronic cerebral vascular ischemia, atherosclerosis. A mathematic formula was calculated to predict an open-angle glaucoma development in patients with PEX. Conclusions. The risk factors of the open-angle glaucoma development in patients with PEX were detected the following: the degree of PEX manifestations, thickness of the lens, the age of patients, the presence of arterial hypertension, ischemic heart disease, chronic cerebral vascular ischemia, atherosclerosis.

Keywords

• pseudoexfoliation syndrome
• primary open-angle glaucoma
• cardio-vascular disease
• risk factors