Marine Drugs (Jun 2016)

Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

  • Min Zhao,
  • Shimiao Cheng,
  • Weiping Yuan,
  • Yiyuan Xi,
  • Xiubao Li,
  • Jianyong Dong,
  • Kexin Huang,
  • Kirk R. Gustafson,
  • Pengcheng Yan

DOI
https://doi.org/10.3390/md14060111
Journal volume & issue
Vol. 14, no. 6
p. 111

Abstract

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Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM.

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