MicroRNA‐204‐5p: A pivotal tumor suppressor

Abstract

Abstract MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. MiR‐204‐5p is frequently downregulated in various cancer types and is related to the clinicopathological characteristics and prognosis of cancer patients. So far, many studies have determined that miR‐204‐5p functions as a tumor suppressor for its extensive and powerful capacity to inhibit tumor proliferation, metastasis, autophagy, and chemoresistance in multiple cancer types. MiR‐204‐5p appears to be a promising prognostic biomarker and a therapeutic target for human cancers. This review summarized the latest advances on the role of miR‐204‐5p in human cancers.

Keywords

• microRNA
• miR‐204‐5p
• tumor suppressor
• cancer
• gene regulation