The Effect of Alcoholic Extract of Morus Alba Leaves on Learning and Spatial Memory in Male Rats

Abstract

Background and Objectives: Various diseases, such as multiple sclerosis, Parkinson, Alzheimer, and dementia lead to impairment in learning and memory. Several studies have been performed to investigate the effects of medicinalal plants on improvement of learning and memory and prevention of these disorders. In the present study, the effect of alcoholic extract of Morus Alba leaves was investigated on learning and spatial memory in male rats. Methods: This study was performed on 32 male Wistar rats. Animals were assigned to four groups, including control group and 3 groups receiving alcoholic extract of Morus Alba leaves at doses of 100, 200, and 400mg/kg. This extract was daily administered by gavage. After one month, learning and spatial memory were evaluated by Morris water maze. Results: Administration of alcoholic extract of Morus Alba at all doses led to improvement of learning process in rats. Also, this extract at the dose of 400mg/kg improved spatial memory in rats. Conclusion: The results of this study showed that administration of alcoholic extract of Morus Alba leads to increases in learning and consolidation of spatial memory in healthy rats.

Keywords

• morus alba leavs
• spatial memory
• learning
• morris water maze