Frontiers in Chemistry (Mar 2021)

Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra

  • Bingyang Zhang,
  • Di Liu,
  • Wenyue Ji,
  • Kouharu Otsuki,
  • Koji Higai,
  • Feng Zhao,
  • Wei Li,
  • Kazuo Koike,
  • Feng Qiu

DOI
https://doi.org/10.3389/fchem.2021.649287
Journal volume & issue
Vol. 9

Abstract

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Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.

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