Nature Communications (Aug 2018)
Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
- Marija Kojic,
- Monika Gaik,
- Bence Kiska,
- Anna Salerno-Kochan,
- Sarah Hunt,
- Angelo Tedoldi,
- Sergey Mureev,
- Alun Jones,
- Belinda Whittle,
- Laura A. Genovesi,
- Christelle Adolphe,
- Darren L. Brown,
- Jennifer L. Stow,
- Kirill Alexandrov,
- Pankaj Sah,
- Sebastian Glatt,
- Brandon J. Wainwright
Affiliations
- Marija Kojic
- Institute for Molecular Bioscience, the University of Queensland
- Monika Gaik
- Max Planck Research Group at the Malopolska Centre of Biotechnology, Jagiellonian University
- Bence Kiska
- Institute for Molecular Bioscience, the University of Queensland
- Anna Salerno-Kochan
- Max Planck Research Group at the Malopolska Centre of Biotechnology, Jagiellonian University
- Sarah Hunt
- Queensland Brain Institute, University of Queensland
- Angelo Tedoldi
- Queensland Brain Institute, University of Queensland
- Sergey Mureev
- Institute for Molecular Bioscience, the University of Queensland
- Alun Jones
- Institute for Molecular Bioscience, the University of Queensland
- Belinda Whittle
- John Curtin School of Medical Research, Australian National University
- Laura A. Genovesi
- Institute for Molecular Bioscience, the University of Queensland
- Christelle Adolphe
- Institute for Molecular Bioscience, the University of Queensland
- Darren L. Brown
- Institute for Molecular Bioscience, the University of Queensland
- Jennifer L. Stow
- Institute for Molecular Bioscience, the University of Queensland
- Kirill Alexandrov
- Institute for Molecular Bioscience, the University of Queensland
- Pankaj Sah
- Queensland Brain Institute, University of Queensland
- Sebastian Glatt
- Max Planck Research Group at the Malopolska Centre of Biotechnology, Jagiellonian University
- Brandon J. Wainwright
- Institute for Molecular Bioscience, the University of Queensland
- DOI
- https://doi.org/10.1038/s41467-018-05765-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.
