Nature Communications (Apr 2021)
Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
- Hao Huang,
- Jianyang Hu,
- Alishba Maryam,
- Qinghua Huang,
- Yuchen Zhang,
- Saravanan Ramakrishnan,
- Jingyu Li,
- Haiying Ma,
- Victor W. S. Ma,
- Wah Cheuk,
- Grace Y. K. So,
- Wei Wang,
- William C. S. Cho,
- Liang Zhang,
- Kui Ming Chan,
- Xin Wang,
- Y. Rebecca Chin
Affiliations
- Hao Huang
- Department of Biomedical Sciences, City University of Hong Kong
- Jianyang Hu
- Department of Biomedical Sciences, City University of Hong Kong
- Alishba Maryam
- Department of Biomedical Sciences, City University of Hong Kong
- Qinghua Huang
- Department of Breast Surgery, The Affiliate Tumor Hospital, Guangxi Medical University
- Yuchen Zhang
- Department of Biomedical Sciences, City University of Hong Kong
- Saravanan Ramakrishnan
- Department of Biomedical Sciences, City University of Hong Kong
- Jingyu Li
- Department of Biomedical Sciences, City University of Hong Kong
- Haiying Ma
- Department of Biomedical Sciences, City University of Hong Kong
- Victor W. S. Ma
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Wah Cheuk
- Department of Pathology, Queen Elizabeth Hospital
- Grace Y. K. So
- Department of Pathology, Queen Elizabeth Hospital
- Wei Wang
- Department of Biomedical Sciences, City University of Hong Kong
- William C. S. Cho
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Liang Zhang
- Department of Biomedical Sciences, City University of Hong Kong
- Kui Ming Chan
- Department of Biomedical Sciences, City University of Hong Kong
- Xin Wang
- Department of Biomedical Sciences, City University of Hong Kong
- Y. Rebecca Chin
- Department of Biomedical Sciences, City University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-021-22445-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1, MET and ANLN.
