Nature Communications (Feb 2020)
A case report of multiple primary prostate tumors with differential drug sensitivity
- Scott Wilkinson,
- Stephanie A. Harmon,
- Nicholas T. Terrigino,
- Fatima Karzai,
- Peter A. Pinto,
- Ravi A. Madan,
- David J. VanderWeele,
- Ross Lake,
- Rayann Atway,
- John R. Bright,
- Nicole V. Carrabba,
- Shana Y. Trostel,
- Rosina T. Lis,
- Guinevere Chun,
- James L. Gulley,
- Maria J. Merino,
- Peter L. Choyke,
- Huihui Ye,
- William L. Dahut,
- Baris Turkbey,
- Adam G. Sowalsky
Affiliations
- Scott Wilkinson
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Stephanie A. Harmon
- Molecular Imaging Program, National Cancer Institute
- Nicholas T. Terrigino
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Fatima Karzai
- Genitourinary Malignancies Branch, National Cancer Institute
- Peter A. Pinto
- Urologic Oncology Branch, National Cancer Institute
- Ravi A. Madan
- Genitourinary Malignancies Branch, National Cancer Institute
- David J. VanderWeele
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Ross Lake
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Rayann Atway
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- John R. Bright
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Nicole V. Carrabba
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Shana Y. Trostel
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Rosina T. Lis
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- Guinevere Chun
- Genitourinary Malignancies Branch, National Cancer Institute
- James L. Gulley
- Genitourinary Malignancies Branch, National Cancer Institute
- Maria J. Merino
- Laboratory of Pathology, National Cancer Institute
- Peter L. Choyke
- Molecular Imaging Program, National Cancer Institute
- Huihui Ye
- Department of Pathology, Beth Israel Deaconess Medical Center
- William L. Dahut
- Genitourinary Malignancies Branch, National Cancer Institute
- Baris Turkbey
- Molecular Imaging Program, National Cancer Institute
- Adam G. Sowalsky
- Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-020-14657-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
Prostate cancer is often a multifocal disease but how best to manage this clinically remains unclear. Here, the authors report a single case study of a patient with two genetically diverse tumours which showed differential response to therapy.
