Clinical Ophthalmology (Jun 2021)

The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings

  • Sen E,
  • Elgin U,
  • Ozen O,
  • Ozturk FG

Journal volume & issue
Vol. Volume 15
pp. 2301 – 2306

Abstract

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Emine Sen,1 Ufuk Elgin,1 Osman Ozen,2 Fikriye Gozde Ozturk3 1University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Glaucoma Department, Ankara, Turkey; 2University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; 3Unye State Hospital, Ordu, TurkeyCorrespondence: Emine SenUniversity of Health Sciences, Ulucanlar Eye Education and Research Hospital, Kale Mahallesi, Ulucanlar Caddesi, No: 59, Altındağ, 06250, Ankara, TurkeyTel +90 505 2438124Fax +90 312 3124827Email [email protected]: To compare bleb morphology and tear tests of glaucoma patients who used trehalose and those who did not use after primary trabeculectomy with mitomycin C (MMC) during the early post-operative period.Methods: This retrospective study included two groups: Group 1 using Trehalose + hyaluronic acid (THA) after primary trabeculectomy with MMC (n = 19) and Group 2 undergoing primary trabeculectomy with MMC (n = 16). The preoperative and postoperative intraocular pressure (IOP), the results of Schirmer, and tear break-up time tests were analyzed. Postoperative bleb morphology was also evaluated at the 1st day, and 1st and 2nd weeks, and 1st and 2nd months.Results: There was no statistically significant difference in preoperative IOP, Schirmer test or tear break-up time between groups. The mean horizontal extent of the blebs was significantly wider in Group 1 at the first week (p= 0.02). Bleb vascularization was also found to be lower in Group 1 at the second week (p= 0.001). The mean bleb height and horizontal extent were significantly higher in Group 1 at the first month (p=0.02, p= 0.03, respectively). The mean bleb horizontal extent was significantly higher in Group 1 at the second month (p= 0.03).Conclusion: The use of trehalose improved surgical success of primary trabeculectomy with MMC in terms of IOP control, post-operative complications, and bleb morphology during the early postoperative period. Trehalose might contribute to wound healing which led to an ideal bleb.Keywords: bleb morphology, glaucoma, Schirmer test, trabeculectomy, trehalose

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