Journal of Allergy and Clinical Immunology: Global (Aug 2023)
The SunBEAm birth cohort: Protocol design
- Corinne Keet, MD, PhD,
- Scott H. Sicherer, MD,
- Supinda Bunyavanich, MD, MPH, MPhil,
- Cynthia Visness, PhD, MPH,
- Patricia C. Fulkerson, MD, PhD,
- Alkis Togias, MD,
- Wendy Davidson, PhD,
- Susan Perry, RN,
- Sanaz Hamrah, PharmD, RPh,
- Agustin Calatroni, MS,
- Katina Robinson, MS,
- Lars Dunaway, PhD,
- Carla M. Davis, MD,
- Sara Anvari, MD,
- Susan M. Leong-Kee, MD,
- Gurjit Khurana Hershey, MD, PhD,
- Emily DeFranco, MD,
- Ashley Devonshire, MD,
- Haejin Kim, MD,
- Christine Joseph, PhD,
- Brent Davidson, MD,
- Noel K. Strong, MD,
- Angela J. Tsuang, MD, MSc,
- Marion Groetch, MS, RDN,
- Julie Wang, MD,
- Jennifer Dantzer, MD, MS,
- Kim Mudd, RN, MSN,
- Abimbola Aina, MD,
- Wayne Shreffler, MD, PhD,
- Qian Yuan, MD, PhD,
- Virginia Simmons, MD,
- Donald Y.M. Leung, MD, PhD,
- Jessica Hui-Beckman, MD,
- Jania Arcia Ramos, MD,
- Sharon Chinthrajah, MD,
- Virginia Winn, MD, PhD,
- Tina Sindher, MD,
- Stacie M. Jones, MD,
- Nirvana A. Manning, MD,
- Amy M. Scurlock, MD,
- Edwin Kim, MD, MS,
- Alison Stuebe, MD,
- James E. Gern, MD,
- Anne Marie Singh, MD,
- Jennifer Krupp, MD,
- Robert A. Wood, MD
Affiliations
- Corinne Keet, MD, PhD
- Department of Pediatrics, University of North Carolina, Chapel Hill, NC; Corresponding author: Corinne Keet, MD, PhD, University of North Carolina, Chapel Hill, Pediatric Allergy/Immunology, 4008 Mary Ellen Jones Building, 116 Manning Drive, Chapel Hill, NC 27514.
- Scott H. Sicherer, MD
- Icahn School of Medicine at Mount Sinai, New York, NY
- Supinda Bunyavanich, MD, MPH, MPhil
- Icahn School of Medicine at Mount Sinai, New York, NY
- Cynthia Visness, PhD, MPH
- Rho Inc, Federal Research Operations, Durham, NC
- Patricia C. Fulkerson, MD, PhD
- Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
- Alkis Togias, MD
- Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
- Wendy Davidson, PhD
- Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
- Susan Perry, RN
- Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
- Sanaz Hamrah, PharmD, RPh
- Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
- Agustin Calatroni, MS
- Rho Inc, Federal Research Operations, Durham, NC
- Katina Robinson, MS
- Rho Inc, Federal Research Operations, Durham, NC
- Lars Dunaway, PhD
- Rho Inc, Federal Research Operations, Durham, NC
- Carla M. Davis, MD
- Department of Pediatrics, Baylor College of Medicine, Houston, Tex
- Sara Anvari, MD
- Department of Pediatrics, Baylor College of Medicine, Houston, Tex
- Susan M. Leong-Kee, MD
- Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Tex
- Gurjit Khurana Hershey, MD, PhD
- Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
- Emily DeFranco, MD
- University of Cincinnati, Cincinnati, Ohio
- Ashley Devonshire, MD
- Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
- Haejin Kim, MD
- Henry Ford Health, Detroit, Mich
- Christine Joseph, PhD
- Henry Ford Health, Detroit, Mich
- Brent Davidson, MD
- Henry Ford Health, Detroit, Mich
- Noel K. Strong, MD
- Icahn School of Medicine at Mount Sinai, New York, NY
- Angela J. Tsuang, MD, MSc
- Icahn School of Medicine at Mount Sinai, New York, NY
- Marion Groetch, MS, RDN
- Icahn School of Medicine at Mount Sinai, New York, NY
- Julie Wang, MD
- Icahn School of Medicine at Mount Sinai, New York, NY
- Jennifer Dantzer, MD, MS
- Department of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Md
- Kim Mudd, RN, MSN
- Department of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Md
- Abimbola Aina, MD
- Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, Md
- Wayne Shreffler, MD, PhD
- Massachusetts General Hospital, Boston, Mass
- Qian Yuan, MD, PhD
- Massachusetts General Hospital, Newton-Wellesley Hospital, Newton, Mass
- Virginia Simmons, MD
- Massachusetts General Hospital, Newton-Wellesley Hospital, Newton, Mass
- Donald Y.M. Leung, MD, PhD
- National Jewish Health, Denver, Colo
- Jessica Hui-Beckman, MD
- National Jewish Health, Denver, Colo
- Jania Arcia Ramos, MD
- Saint Joseph Hospital of Obstetrics and Gynecology, Denver, Colo
- Sharon Chinthrajah, MD
- Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, Calif
- Virginia Winn, MD, PhD
- Division Maternal Fetal Medicine and Obstetrics, Stanford University, Palo Alto, Calif
- Tina Sindher, MD
- Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, Calif
- Stacie M. Jones, MD
- University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, Ark
- Nirvana A. Manning, MD
- University of Arkansas for Medical Sciences, Little Rock, Ark
- Amy M. Scurlock, MD
- University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, Ark
- Edwin Kim, MD, MS
- Department of Pediatrics, University of North Carolina, Chapel Hill, NC
- Alison Stuebe, MD
- Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC
- James E. Gern, MD
- Department of Pediatrics, University of Wisconsin, Madison, Wis
- Anne Marie Singh, MD
- Department of Pediatrics, University of Wisconsin, Madison, Wis
- Jennifer Krupp, MD
- Maternal and Fetal Medicine, Obstetrics and Gynecology, SSM Health, Madison, Wis
- Robert A. Wood, MD
- Department of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Md
- Journal volume & issue
-
Vol. 2,
no. 3
p. 100124
Abstract
Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.
