Pathomorphological Markers of Overcoming Radioresistance in the Treatment of Cervical Cancer

Abstract

The aim of this study was to study pathomorphological markers of decreasing radioresistance of cervical tumor tissue during radiation therapy and the administration of sodium deoxyribonucleate. Methods and Results: The object of the study was patients with diagnosed cervical cancer (T1/FIGOIB, T1a1-2/FIGOIA1-2, and T1b1-2/FIGOIB1-2; NX0 and M0). All patients in the study were divided into 2 groups. The main group (MG) included 40 patients receiving combination of standard chemoradiotherapy with sodium deoxyribonucleate (5ml intramuscularly for 20 days). The comparison group (CG) included 23 patients receiving only standard chemoradiotherapy. Histological and immunohistochemical analysis was performed. Conclusion: Against the background of complex therapy, the TLR9 expression indices in the patients of the MG were 24%-36% higher than the indices in the patients of the CG. The inclusion of sodium deoxyribonucleate—a TLR9 agonist—in the chemoradiotherapy regimen for cervical cancer has great potential for stimulating the TLR9 expression in immunocompetent cells of the tumor microenvironment.

Keywords

• radioresistance
• tlr9 expression
• cervical cancer
• pathomorphological markers