Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release

Chuan Xie; Qinqin Xiong; Yuanzhi Wei; Xin Li; Jiajun Hu; Min He; Shinan Wei; Jia Yu; Sha Cheng; Mashaal Ahmad; Yufei Liu; Sihai Luo; Xi Zeng; Jie Yu; Heng Luo

Materials Today Bio (Jun 2023)

Fabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained release

Chuan Xie,
Qinqin Xiong,
Yuanzhi Wei,
Xin Li,
Jiajun Hu,
Min He,
Shinan Wei,
Jia Yu,
Sha Cheng,
Mashaal Ahmad,
Yufei Liu,
Sihai Luo,
Xi Zeng,
Jie Yu,
Heng Luo

Affiliations

Chuan Xie: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, 550025, China
Qinqin Xiong: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China
Yuanzhi Wei: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, 550025, China
Xin Li: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China
Jiajun Hu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China
Min He: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China
Shinan Wei: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China
Jia Yu: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China
Sha Cheng: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China
Mashaal Ahmad: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China
Yufei Liu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang, 550014, China; Corresponding author. Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China.
Sihai Luo: Department of Chemistry, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway; Corresponding author.
Xi Zeng: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, 550025, China
Jie Yu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang, 550014, China
Heng Luo: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China; Corresponding author. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.

Journal volume & issue: Vol. 20
p. 100628

Abstract

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Sustained drug release has attracted increasing interest in targeted drug therapy. However, existing methods of drug therapy suffer drug action time, large fluctuations in the effective concentration of the drug, and the risk of side effects. Here, a biodegradable composite of polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting of electrospun hollow microspheres as sustained-released drug carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate and drug (Erlotinib) release than that of PBAT. Furthermore, PBAT/PVP composites loaded with Erlotinib provide sustained release effect, thus achieving a better efficacy than that after the direct injection of erlotinib due to the fact that the composites allow a high drug concentration in the tumor for a longer period. Hence, this work provides a potential effective solution for clinical drug therapy and tissue engineering using drug microspheres with a sustained release.

Published in Materials Today Bio

ISSN: 2590-0064 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/materials-today-bio

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