Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad; Veronique Seidel; Michalak Izabela; Margalida Monserrat-Mequida; Antoni Sureda; Valeska Ormazabal; Felipe A. Zuniga; Shivaprasad Shetty Mangalpady; Raffaele Pezzani; Alibek Ydyrys; Gulmira Tussupbekova; Miquel Martorell; Daniela Calina; William C. Cho

doi:10.1186/s12964-023-01109-0

Cell Communication and Signaling (May 2023)

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad,
Veronique Seidel,
Michalak Izabela,
Margalida Monserrat-Mequida,
Antoni Sureda,
Valeska Ormazabal,
Felipe A. Zuniga,
Shivaprasad Shetty Mangalpady,
Raffaele Pezzani,
Alibek Ydyrys,
Gulmira Tussupbekova,
Miquel Martorell,
Daniela Calina,
William C. Cho

Affiliations

Javad Sharifi-Rad: Facultad de Medicina, Universidad del Azuay
Veronique Seidel: Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
Michalak Izabela: Department of Advanced Material Technologies, Faculty of Chemistry, Wroclaw University of Science and Technology
Margalida Monserrat-Mequida: Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands—IUNICS
Antoni Sureda: Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands—IUNICS
Valeska Ormazabal: Department of Pharmacology, Faculty of Biological Sciences, University of Concepción
Felipe A. Zuniga: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción
Shivaprasad Shetty Mangalpady: Department of Chemistry, NMAM Institute of Technology
Raffaele Pezzani: Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova
Alibek Ydyrys: Biomedical Research Centre, Al-Farabi Kazakh National University
Gulmira Tussupbekova: Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University
Miquel Martorell: Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción
Daniela Calina: Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova
William C. Cho: Department of Clinical Oncology, Queen Elizabeth Hospital

DOI: https://doi.org/10.1186/s12964-023-01109-0
Journal volume & issue: Vol. 21, no. 1
pp. 1 – 18

Abstract

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Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract

Published in Cell Communication and Signaling

ISSN: 1478-811X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General): Cytology
Website: https://biosignaling.biomedcentral.com/

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Abstract

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