Nature Communications (Jul 2021)

NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir

  • Rina Nishii,
  • Takanori Mizuno,
  • Daniel Rehling,
  • Colton Smith,
  • Brandi L. Clark,
  • Xujie Zhao,
  • Scott A. Brown,
  • Brandon Smart,
  • Takaya Moriyama,
  • Yuji Yamada,
  • Tatsuo Ichinohe,
  • Makoto Onizuka,
  • Yoshiko Atsuta,
  • Lei Yang,
  • Wenjian Yang,
  • Paul G. Thomas,
  • Pål Stenmark,
  • Motohiro Kato,
  • Jun J. Yang

DOI
https://doi.org/10.1038/s41467-021-24509-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al. show that diphosphatase NUDT15 hydrolyzes ACV and GCV, therewith reducing NNA activity in vitro and link NUDT15 variation to inter-patient variability in ACV and GCV therapeutic effects.