Journal of Pure and Applied Microbiology (Mar 2024)

Leveraging Neurospora crassa Fungus and Carboxypeptidase A1 Enzyme to Illuminate Microscale Biodiversity Changes in Response to Global Shifts

  • Supajit Sraphet,
  • Chaisri Tharasawatdipipat,
  • Sivapan Choo-in,
  • Pantip Kayee,
  • Bagher Javadi

DOI
https://doi.org/10.22207/JPAM.18.1.25
Journal volume & issue
Vol. 18, no. 1
pp. 419 – 429

Abstract

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The profound impacts of global changes on biodiversity necessitate a more comprehensive documentation, particularly at the microscale level. To achieve precise and rapid insights into this unique diversity, the choice of an ideal species candidate is crucial. Neurospora crassa, a well-established organism in the field of biology, emerges as a promising candidate for this purpose. In our study, we explore the potential of the Carboxypeptidase A1 (CPA1) enzyme as a valuable tool for profiling global diversity. Our investigation has revealed that CPA1 possesses distinctive characteristics, notably its conserved solvent accessibility. This unique feature makes CPA1 an invaluable asset for microscale studies of global changes. The insights presented in our study serve as a practical blueprint, showcasing the application of structural biology in understanding diversity and global changes within microscale environments.

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