Nature Communications (Feb 2019)
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
- Zhongyi Hu,
- Junzhi Zhou,
- Junjie Jiang,
- Jiao Yuan,
- Youyou Zhang,
- Xuepeng Wei,
- Nicki Loo,
- Yueying Wang,
- Yutian Pan,
- Tianli Zhang,
- Xiaomin Zhong,
- Meixiao Long,
- Kathleen T. Montone,
- Janos L. Tanyi,
- Yi Fan,
- Tian-Li Wang,
- Ie-Ming Shih,
- Xiaowen Hu,
- Lin Zhang
Affiliations
- Zhongyi Hu
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Junzhi Zhou
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Junjie Jiang
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Jiao Yuan
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Youyou Zhang
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Xuepeng Wei
- Department of Biochemistry and Biophysics, University of Pennsylvania
- Nicki Loo
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Yueying Wang
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Yutian Pan
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Tianli Zhang
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Xiaomin Zhong
- Center for Stem Cell Biology and Tissue Engineering, Department of Biology, Zhongshan School of Medicine, Sun Yat-Sen University
- Meixiao Long
- Division of Hematology, Department of Internal Medicine, Ohio State University
- Kathleen T. Montone
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Janos L. Tanyi
- Department of Obstetrics and Gynecology, University of Pennsylvania
- Yi Fan
- Department of Radiation Oncology, University of Pennsylvania
- Tian-Li Wang
- Departments of Gynecology and Obstetrics, Johns Hopkins University School of Medicine
- Ie-Ming Shih
- Departments of Gynecology and Obstetrics, Johns Hopkins University School of Medicine
- Xiaowen Hu
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- Lin Zhang
- Center for Research on Reproduction and Women’s Health, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-019-08554-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Targeting histone acetylation modulators (HAMPs) is a promising avenue of drug discovery in cancer research. Here, the authors integrate multi-dimensional genomic profiles to systematically investigate recurrent genomic alterations in HAMPs, identifying potential therapeutic targets for precision epigenetic treatment.
