Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy

Allison L. Fisher; Veena Sangkhae; Kamila Balušíková; Nicolaos J. Palaskas; Tomas Ganz; Elizabeta Nemeth

doi:10.1038/s41467-021-24333-z

Nature Communications (Jun 2021)

Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy

Allison L. Fisher,
Veena Sangkhae,
Kamila Balušíková,
Nicolaos J. Palaskas,
Tomas Ganz,
Elizabeta Nemeth

Affiliations

Allison L. Fisher: Molecular, Cellular & Integrative Physiology Graduate Program, University of California, Los Angeles
Veena Sangkhae: Center for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles
Kamila Balušíková: Department of Biochemistry, Cell and Molecular Biology & Center for Research of Diabetes, Metabolism and Nutrition, Third Faculty of Medicine, Charles University
Nicolaos J. Palaskas: Center for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles
Tomas Ganz: Center for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles
Elizabeta Nemeth: Center for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-021-24333-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Iron is essential during pregnancy for embryo and placental development and maternal health. However, in this study using mouse models, the authors demonstrate that excess maternal iron causes adverse embryo outcomes in pregnancies with underlying systemic inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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