Nature Communications (Aug 2018)

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum

  • Marie-Christine Klein,
  • Katharina Zimmermann,
  • Stefan Schorr,
  • Martina Landini,
  • Patrick A. W. Klemens,
  • Jacqueline Altensell,
  • Martin Jung,
  • Elmar Krause,
  • Duy Nguyen,
  • Volkhard Helms,
  • Jens Rettig,
  • Claudia Fecher-Trost,
  • Adolfo Cavalié,
  • Markus Hoth,
  • Ivan Bogeski,
  • H. Ekkehard Neuhaus,
  • Richard Zimmermann,
  • Sven Lang,
  • Ilka Haferkamp

DOI
https://doi.org/10.1038/s41467-018-06003-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Endoplasmic reticulum (ER) functioning requires a constant supply of ATP, but the exchanger required for ATP uptake into the ER is unknown. Here, the authors report that SLC35B1, here named AXER, or ATP/ADP exchanger into the ER, can transport ATP into the ER.