Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors

Guo Siquan; Qin Feng; Wang Jiang; Ding Yongqing; You Jianqiang; Chao Changjiang

doi:10.5937/jomb0-44057

Journal of Medical Biochemistry (Jan 2024)

Correlation of serum IL-2 and IFN-γ levels with clinical prognosis of nasopharyngeal carcinoma patients and analysis of risk factors

Guo Siquan,
Qin Feng,
Wang Jiang,
Ding Yongqing,
You Jianqiang,
Chao Changjiang

Affiliations

Guo Siquan: Third Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, China
Qin Feng: Nanjing Medical University, Changzhou Third People's Hospital, Changzhou Medical Center, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, China
Wang Jiang: Third Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, China
Ding Yongqing: First Affiliated Hospital of Hebei North University, Department of Otorhinolaryngology Head and Neck Surgery, Zhangjiakou, China
You Jianqiang: Third Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, China
Chao Changjiang: Third Affiliated Hospital of Soochow University, Department of Otorhinolaryngology Head and Neck Surgery, Changzhou, China

DOI: https://doi.org/10.5937/jomb0-44057
Journal volume & issue: Vol. 43, no. 1
pp. 50 – 56

Abstract

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Background: This study aims to investigate the correlation between serum levels of interleukin-2 (IL-2) and interferong (IFN-g) and the clinical prognosis of patients with nasopharyngeal carcinoma (NPC). Additionally, the study aims to analyse the risk factors associated with this correlation. Methods: The clinical data of 195 NPC patients admitted to our hospital from October 2020 to October 2022 were selected for a retrospective study. Based on the Glasgow score, patients were divided into two groups: the good prognosis group (group g), consisting of patients who scored 0 points, and the poor prognosis group (group p), consisting of patients who scored 1-2 points. The levels of serum IL-2 and IFN-g were compared between the two groups, and the clinical values of serum IL-2 and IFN-g in the prognosis of patients were analysed. The clinical parameters of the patients were collected, and the risk factors affecting the prognosis of NPC were analysed by univariate and multivariate logistic regression. Results: Among 195 patients, 125 were in group g, and 70 were in group p. The levels of IL-2 and IFN-g in group g were higher than in group p (P<0.05). The predictive AUC (95%CI) of IL-2 and IFN-g were 0.846 (0.791-0.902) and 0.851 (0.797-0.904), respectively (P<0.05). Logistic regression analysis showed that age, tumour diameter, clinical stages and degree of differentiation were risk factors for the prognosis of NPC patients. Conclusion: The levels of serum IL-2 and IFN-g are closely related to the prognosis of NPC patients and have certain value in evaluating the prognosis of patients. The age, tumour diameter, tumour staging and degree of tumour differentiation are all risk factors affecting the prognosis of patients, which can provide a reference for selecting clinical treatment methods and evaluating prognosis.

Published in Journal of Medical Biochemistry

ISSN: 1452-8258 (Print); 1452-8266 (Online)
Publisher: Society of Medical Biochemists of Serbia, Belgrade
Country of publisher: Serbia
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://scindeks.ceon.rs/journaldetails.aspx?issn=1452-8258&lang=en

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