The Ribosome Biogenesis—Cancer Connection

Abstract

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the reasons for the nucleolar changes in cancer cells and their exploitation in tumor pathology, 2) defined the importance of the inhibition of ribosome biogenesis in cancer chemotherapy and 3) focused the attention on alterations of ribosome biogenesis in the pathogenesis of cancer. This review summarizes the research milestones regarding these relevant relationships between ribosome biogenesis and cancer. The structure and function of the nucleolus will also be briefly described.

Keywords

• nucleolus
• ribosome biogenesis
• ribosomal proteins
• p53
• AgNORs
• tumour pathology
• chronic inflammatory diseases
• ribosomopathies
• tumourigenesis
• cancer chemotherapy