Nature Communications (Aug 2017)
Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis
- Yongmei Liu,
- Lindsay M. Reynolds,
- Jingzhong Ding,
- Li Hou,
- Kurt Lohman,
- Tracey Young,
- Wei Cui,
- Zhiqing Huang,
- Carole Grenier,
- Ma Wan,
- Hendrik G. Stunnenberg,
- David Siscovick,
- Lifang Hou,
- Bruce M. Psaty,
- Stephen S. Rich,
- Jerome I. Rotter,
- Joel D. Kaufman,
- Gregory L. Burke,
- Susan Murphy,
- David R. Jacobs,
- Wendy Post,
- Ina Hoeschele,
- Douglas A. Bell,
- David Herrington,
- John S. Parks,
- Russell P. Tracy,
- Charles E. McCall,
- James H. Stein
Affiliations
- Yongmei Liu
- Department of Epidemiology and Prevention, Wake Forest School of Medicine
- Lindsay M. Reynolds
- Department of Epidemiology and Prevention, Wake Forest School of Medicine
- Jingzhong Ding
- Department of Internal Medicine, Wake Forest School of Medicine
- Li Hou
- Department of Epidemiology and Prevention, Wake Forest School of Medicine
- Kurt Lohman
- Department of Biostatistical Sciences, Wake Forest School of Medicine
- Tracey Young
- Department of Epidemiology and Prevention, Wake Forest School of Medicine
- Wei Cui
- Department of Internal Medicine, Wake Forest School of Medicine
- Zhiqing Huang
- Duke University
- Carole Grenier
- Duke University
- Ma Wan
- National Institute of Environmental Health Sciences, National Institutes of Health
- Hendrik G. Stunnenberg
- Department of Molecular Biology, Nijmegen Centre for Molecular Life Sciences (NCMLS)
- David Siscovick
- New York Academy of Medicine
- Lifang Hou
- Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center
- Joel D. Kaufman
- Department of Environmental and Occupational Health Sciences, Medicine and Epidemiology, University of Washington
- Gregory L. Burke
- Department of Epidemiology and Prevention, Wake Forest School of Medicine
- Susan Murphy
- Duke University
- David R. Jacobs
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Wendy Post
- Department of Pathology and Cardiology, Johns Hopkins University
- Ina Hoeschele
- Biocomplexity Institute and Department of Statistics
- Douglas A. Bell
- National Institute of Environmental Health Sciences, National Institutes of Health
- David Herrington
- Department of Internal Medicine, Wake Forest School of Medicine
- John S. Parks
- Department of Internal Medicine-Section on Molecular Medicine, Wake Forest School of Medicine
- Russell P. Tracy
- Department of Pathology, University of Vermont
- Charles E. McCall
- Department of Internal Medicine-Section on Molecular Medicine, Wake Forest School of Medicine
- James H. Stein
- University of Wisconsin School of Medicine and Public Health
- DOI
- https://doi.org/10.1038/s41467-017-00517-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
The molecular mechanisms mediating the impact of environmental factors in atherosclerosis are unclear. Here, the authors examine CD14+ blood monocyte’s transcriptome and epigenome signatures to find differential methylation and expression of ARID5B to be associated with human atherosclerosis.
