Frontiers in Immunology (Dec 2023)
Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis
- Kunwadee Noonong,
- Kunwadee Noonong,
- Moragot Chatatikun,
- Moragot Chatatikun,
- Sirirat Surinkaew,
- Sirirat Surinkaew,
- Manas Kotepui,
- Rahni Hossain,
- Kingkan Bunluepuech,
- Chanittha Noothong,
- Aman Tedasen,
- Aman Tedasen,
- Wiyada Kwanhian Klangbud,
- Wiyada Kwanhian Klangbud,
- Motoki Imai,
- Motoki Imai,
- Fumitaka Kawakami,
- Fumitaka Kawakami,
- Fumitaka Kawakami,
- Makoto Kubo,
- Makoto Kubo,
- Makoto Kubo,
- Yoshimasa Kitagawa,
- Hiroshi Ichikawa,
- Takuro Kanekura,
- Suriyan Sukati,
- Voravuth Somsak,
- Voravuth Somsak,
- Lunla Udomwech,
- Takafumi Ichikawa,
- Takafumi Ichikawa,
- Veeranoot Nissapatorn,
- Veeranoot Nissapatorn,
- Jitbanjong Tangpong,
- Jitbanjong Tangpong,
- Hiroko P. Indo,
- Hiroko P. Indo,
- Hideyuki J. Majima,
- Hideyuki J. Majima
Affiliations
- Kunwadee Noonong
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Kunwadee Noonong
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Moragot Chatatikun
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Moragot Chatatikun
- Center of Excellence Research for Melioidosis and Microorganisms, Walailak University, Nakhon Si Thammarat, Thailand
- Sirirat Surinkaew
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Sirirat Surinkaew
- Center of Excellence Research for Melioidosis and Microorganisms, Walailak University, Nakhon Si Thammarat, Thailand
- Manas Kotepui
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Rahni Hossain
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Kingkan Bunluepuech
- School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand
- Chanittha Noothong
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Aman Tedasen
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Aman Tedasen
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Wiyada Kwanhian Klangbud
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Wiyada Kwanhian Klangbud
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Motoki Imai
- Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Motoki Imai
- Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Fumitaka Kawakami
- Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Fumitaka Kawakami
- Department of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan
- Fumitaka Kawakami
- Department of Health Administration, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Makoto Kubo
- Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Makoto Kubo
- Division of Microbiology, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Makoto Kubo
- 0Department of Environmental Microbiology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan
- Yoshimasa Kitagawa
- 1Oral Diagnosis and Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
- Hiroshi Ichikawa
- 2Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
- Takuro Kanekura
- 3Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
- Suriyan Sukati
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Voravuth Somsak
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Voravuth Somsak
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Lunla Udomwech
- School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand
- Takafumi Ichikawa
- Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan
- Takafumi Ichikawa
- Department of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan
- Veeranoot Nissapatorn
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Veeranoot Nissapatorn
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Jitbanjong Tangpong
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Jitbanjong Tangpong
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Hiroko P. Indo
- 4Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
- Hiroko P. Indo
- 5Amanogawa Galaxy Astronomy Research Center, Kagoshima University Graduate School of Engineering, Kagoshima, Japan
- Hideyuki J. Majima
- School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- Hideyuki J. Majima
- Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand
- DOI
- https://doi.org/10.3389/fimmu.2023.1275001
- Journal volume & issue
-
Vol. 14
Abstract
SignificanceThis review discusses the coronavirus disease 2019 (COVID-19) pathophysiology in the context of diabetes and intracellular reactions by COVID-19, including mitochondrial oxidative stress storms, mitochondrial ROS storms, and long COVID.Recent advancesThe long COVID is suffered in ~10% of the COVID-19 patients. Even the virus does not exist, the patients suffer the long COVID for even over a year, This disease could be a mitochondria dysregulation disease.Critical issuesPatients who recover from COVID-19 can develop new or persistent symptoms of multi-organ complications lasting weeks or months, called long COVID. The underlying mechanisms involved in the long COVID is still unclear. Once the symptoms of long COVID persist, they cause significant damage, leading to numerous, persistent symptoms.Future directionsA comprehensive map of the stages and pathogenetic mechanisms related to long COVID and effective drugs to treat and prevent it are required, which will aid the development of future long COVID treatments and symptom relief.
Keywords
