Nature Communications (Oct 2017)
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
- Martin G. Dalin,
- Nora Katabi,
- Marta Persson,
- Ken-Wing Lee,
- Vladimir Makarov,
- Alexis Desrichard,
- Logan A. Walsh,
- Lyndsay West,
- Zaineb Nadeem,
- Deepa Ramaswami,
- Jonathan J. Havel,
- Fengshen Kuo,
- Kalyani Chadalavada,
- Gouri J. Nanjangud,
- Ian Ganly,
- Nadeem Riaz,
- Alan L. Ho,
- Cristina R. Antonescu,
- Ronald Ghossein,
- Göran Stenman,
- Timothy A. Chan,
- Luc G. T. Morris
Affiliations
- Martin G. Dalin
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Nora Katabi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Marta Persson
- Sahlgrenska Cancer Center, Department of Pathology and Genetics, University of Gothenburg
- Ken-Wing Lee
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Vladimir Makarov
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Alexis Desrichard
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Logan A. Walsh
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Lyndsay West
- Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Zaineb Nadeem
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Deepa Ramaswami
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Jonathan J. Havel
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Fengshen Kuo
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Kalyani Chadalavada
- Molecular Cytogenetics Core Facility, Memorial Sloan Kettering Cancer Center
- Gouri J. Nanjangud
- Molecular Cytogenetics Core Facility, Memorial Sloan Kettering Cancer Center
- Ian Ganly
- Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center
- Nadeem Riaz
- Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center
- Alan L. Ho
- Head and Neck Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Cristina R. Antonescu
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ronald Ghossein
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Göran Stenman
- Sahlgrenska Cancer Center, Department of Pathology and Genetics, University of Gothenburg
- Timothy A. Chan
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Luc G. T. Morris
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-017-01178-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a potential hallmark of MECA.
