IDCases (Jan 2023)

Japanese spotted fever with post-infectious encephalitis

  • Takafumi Wada,
  • Hitoshi Mori,
  • Kouji Kida,
  • Katsuro Shindo

Journal volume & issue
Vol. 31
p. e01658

Abstract

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Japanese spotted fever (JSF) is a rickettsial disease caused by Rickettsia japonica. To the best of our knowledge, there have only been five reported cases of JSF involving the central nervous system. A 74-year-old man was admitted after 1 week of fever and maculopapular rash. JSF was definitively diagnosed by PCR; however, the patient showed mental disturbance and abnormal behavior. After intravenous immunoglobulin, his mental state and behavior improved. The findings of cerebrospinal fluid analysis, electroencephalography, and 99 mTcHM-PAO single photon computed emission tomography suggested post-infectious encephalitis. JSF causes post-infectious encephalitis and early treatment is recommended.

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