Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank

Solja T. Nyberg; G David Batty; Jaana Pentti; Ida E H Madsen; Lars Alfredsson; Jakob B. Bjorner; Marianne Borritz; Hermann Burr; Jenni Ervasti; Marcel Goldberg; Markus Jokela; Anders Knutsson; Aki Koskinen; Tea Lallukka; Joni V. Lindbohm; Martin L. Nielsen; Tuula Oksanen; Jan H. Pejtersen; Olli Pietiläinen; Ossi Rahkonen; Reiner Rugulies; Martin J. Shipley; Pyry N. Sipilä; Jeppe K. Sørensen; Sari Stenholm; Sakari Suominen; Ari Väänänen; Jussi Vahtera; Marianna Virtanen; Hugo Westerlund; Marie Zins; Archana Singh-Manoux; Mika Kivimäki

The Lancet Regional Health. Europe (Aug 2022)

Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank

Solja T. Nyberg,
G David Batty,
Jaana Pentti,
Ida E H Madsen,
Lars Alfredsson,
Jakob B. Bjorner,
Marianne Borritz,
Hermann Burr,
Jenni Ervasti,
Marcel Goldberg,
Markus Jokela,
Anders Knutsson,
Aki Koskinen,
Tea Lallukka,
Joni V. Lindbohm,
Martin L. Nielsen,
Tuula Oksanen,
Jan H. Pejtersen,
Olli Pietiläinen,
Ossi Rahkonen,
Reiner Rugulies,
Martin J. Shipley,
Pyry N. Sipilä,
Jeppe K. Sørensen,
Sari Stenholm,
Sakari Suominen,
Ari Väänänen,
Jussi Vahtera,
Marianna Virtanen,
Hugo Westerlund,
Marie Zins,
Archana Singh-Manoux,
Mika Kivimäki

Affiliations

Solja T. Nyberg: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland; Faculty of Social Sciences, University of Tampere, Tampere, Finland; Finnish Institute of Occupational Health, Helsinki, Finland; Corresponding author at: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland.
G David Batty: Department of Epidemiology and Public Health, University College London, London, UK
Jaana Pentti: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
Ida E H Madsen: National Research Centre for the Working Environment, Copenhagen, Denmark
Lars Alfredsson: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, Sweden
Jakob B. Bjorner: National Research Centre for the Working Environment, Copenhagen, Denmark
Marianne Borritz: Bispebjerg University Hospital, Copenhagen, Denmark
Hermann Burr: Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany
Jenni Ervasti: Finnish Institute of Occupational Health, Helsinki, Finland
Marcel Goldberg: Paris Descartes University, Paris, France; Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France
Markus Jokela: Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Anders Knutsson: Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden
Aki Koskinen: Finnish Institute of Occupational Health, Helsinki, Finland
Tea Lallukka: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland
Joni V. Lindbohm: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland
Martin L. Nielsen: AS3 Companies, Viby J, Denmark
Tuula Oksanen: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
Jan H. Pejtersen: VIVE-The Danish Center for Social Science Research, Copenhagen, Denmark
Olli Pietiläinen: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland
Ossi Rahkonen: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland
Reiner Rugulies: National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark
Martin J. Shipley: Department of Epidemiology and Public Health, University College London, London, UK
Pyry N. Sipilä: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland
Jeppe K. Sørensen: National Research Centre for the Working Environment, Copenhagen, Denmark
Sari Stenholm: Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
Sakari Suominen: Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; School of Health Science, University of Skövde, Skövde, Sweden
Ari Väänänen: Finnish Institute of Occupational Health, Helsinki, Finland
Jussi Vahtera: Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
Marianna Virtanen: School of Educational Sciences and Psychology, University of Eastern Finland, Joensuu, Finland; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Hugo Westerlund: Stress Research Institute, Stockholm University, Stockholm, Sweden
Marie Zins: Paris Descartes University, Paris, France; Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France
Archana Singh-Manoux: Department of Epidemiology and Public Health, University College London, London, UK; Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, France
Mika Kivimäki: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland; Department of Epidemiology and Public Health, University College London, London, UK

Journal volume & issue: Vol. 19
p. 100417

Abstract

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Summary: Background: Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use. Methods: In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines – non-drinking (never or former drinkers); moderate consumption (1–14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study. Findings: During 1·73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29·3 (95%CI 27·9–30·8) years, women 29·8 (29·2–30·4) years)] and moderate drinkers with no binge drinking habit [men 28·7 (28·4–29·0) years, women 29·6 (29·4–29·7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23·4 (20·9–26·0) years, women 24·0 (21·4–26·5) years] and those with self-reported heavy overall consumption and binge drinking [men: 26·0 (25·3–26·8), women 27·5 (26·4–28·5) years]. The pattern of results for alcohol poisoning and self-reported alcohol consumption was similar in UK Biobank. In IPD-Work and UK Biobank, differences in disease-free years between self-reported moderate drinkers and heavy drinkers were 1·5 years or less. Interpretation: Individuals with alcohol poisonings or heavy self-reported overall consumption combined with a binge drinking habit have a marked 3- to 6-year loss in healthy longevity. Differences in disease-free life between categories of self-reported weekly alcohol consumption were smaller. Funding: Medical Research Council, National Institute on Aging, NordForsk, Academy of Finland, Finnish Work Environment Fund.

Published in The Lancet Regional Health. Europe

ISSN: 2666-7762 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Public aspects of medicine
Website: https://www.thelancet.com/journals/lanepe/home

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