Investigation of the Effect of Acamprosate Treatment on Heart Contractions in Alcohol-Dependent Rats

Abstract

Background/ Aim: Chronic alcohol use leads to impaired heart contraction and also causes a direct toxic effect on myocardial function. Acamprosate, which is widely used in alcohol dependence, is not known to have a pharmacological effect on cardiac contraction. Therefore, this study aimed to investigate the effects of acamprosate on the heart muscle. Materials and Methods: A total of 32 female Wistar rats were divided four groups as control (10 mg/kg/g saline) group, alcohol (10 mg/kg/g alcohol + 10 mg/kg/g saline) group, acamprosate (200 mg/kg/g) group and alcohol+ acamprosate groups (10 mg/kg/g alcohol + 200 mg/kg/g acamprosate + 10 mg/kg/g saline). Alcoholic rats were scored for alcohol dependence and withdrawal. After that, the rats were sacrificed, respectively and the heart tissue was removed. The amplitude and contraction frequencies of the atrium tissue taken from the heart tissue were measured in the isolated tissue bath. Results: Alcohol dependence and withdrawal symptoms were observed in the Alcohol group and Alcohol+Acamprosate group (p

Keywords

• alcohol
• alcohol dependence
• acamprosate
• heart contraction
• isolated tissue bath
• alkol
• alkol bağımlılığı
• akamprosat
• kalp kasılması
• izole organ banyosu