Nature Communications (Jan 2022)
Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2
- Kapil Gupta,
- Christine Toelzer,
- Maia Kavanagh Williamson,
- Deborah K. Shoemark,
- A. Sofia F. Oliveira,
- David A. Matthews,
- Abdulaziz Almuqrin,
- Oskar Staufer,
- Sathish K. N. Yadav,
- Ufuk Borucu,
- Frederic Garzoni,
- Daniel Fitzgerald,
- Joachim Spatz,
- Adrian J. Mulholland,
- Andrew D. Davidson,
- Christiane Schaffitzel,
- Imre Berger
Affiliations
- Kapil Gupta
- School of Biochemistry, University of Bristol
- Christine Toelzer
- School of Biochemistry, University of Bristol
- Maia Kavanagh Williamson
- School of Cellular and Molecular Medicine, University of Bristol, University Walk
- Deborah K. Shoemark
- School of Biochemistry, University of Bristol
- A. Sofia F. Oliveira
- School of Biochemistry, University of Bristol
- David A. Matthews
- School of Cellular and Molecular Medicine, University of Bristol, University Walk
- Abdulaziz Almuqrin
- School of Cellular and Molecular Medicine, University of Bristol, University Walk
- Oskar Staufer
- Department for Cellular Biophysics, Max Planck Institute for Medical Research
- Sathish K. N. Yadav
- School of Biochemistry, University of Bristol
- Ufuk Borucu
- School of Biochemistry, University of Bristol
- Frederic Garzoni
- Imophoron Ltd, St. Philips Central, Albert Rd, St. Philips
- Daniel Fitzgerald
- Halo Therapeutics Ltd, St. Philips Central, Albert Rd, St. Philips
- Joachim Spatz
- Department for Cellular Biophysics, Max Planck Institute for Medical Research
- Adrian J. Mulholland
- School of Chemistry, University of Bristol, Cantock’s Close
- Andrew D. Davidson
- School of Cellular and Molecular Medicine, University of Bristol, University Walk
- Christiane Schaffitzel
- School of Biochemistry, University of Bristol
- Imre Berger
- School of Biochemistry, University of Bristol
- DOI
- https://doi.org/10.1038/s41467-021-27881-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
BriSΔ, a SARS-CoV-2 variant from clinical isolate hCoV/England/02/2020, comprises a deletion in a spike cleavage site. The structure and molecular dynamics of this spike provides mechanistic insights into how the deletion modulates virus infectivity.
