Engineering species-like barriers to sexual reproduction

Maciej Maselko; Stephen C. Heinsch; Jeremy M. Chacón; William R. Harcombe; Michael J. Smanski

doi:10.1038/s41467-017-01007-3

Nature Communications (Oct 2017)

Engineering species-like barriers to sexual reproduction

Maciej Maselko,
Stephen C. Heinsch,
Jeremy M. Chacón,
William R. Harcombe,
Michael J. Smanski

Affiliations

Maciej Maselko: Department of Biochemistry, Molecular Biology, and Biophysics and BioTechnology Institute, University of Minnesota – Twin Cities
Stephen C. Heinsch: Department of Biochemistry, Molecular Biology, and Biophysics and BioTechnology Institute, University of Minnesota – Twin Cities
Jeremy M. Chacón: Department of Ecology, Evolution, and Behavior and BioTechnology Institute, University of Minnesota – Twin Cities
William R. Harcombe: Department of Ecology, Evolution, and Behavior and BioTechnology Institute, University of Minnesota – Twin Cities
Michael J. Smanski: Department of Biochemistry, Molecular Biology, and Biophysics and BioTechnology Institute, University of Minnesota – Twin Cities

DOI: https://doi.org/10.1038/s41467-017-01007-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 7

Abstract

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Genetic isolation of a genetically modified organism represents a useful strategy for biocontainment. Here the authors use dCas9-VP64-driven gene expression to construct a ‘species-like’ barrier to reproduction between two otherwise compatible populations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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