PCSK9 and LDL-C: The Role of Exercise

Abstract

Abstracts Purpose Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a pivotal regulator of low lipoprotein-cholesterol (LDL-C) and LDL receptor (LDLR) metabolism, and the interest in PCSK9 has increased in cardiovascular diseases. Exercise reduces blood LDL-C via PCSK9-LDLR pathway in the liver and the vasculature. However, the mechanism of exercise-induced inhibition of PCSK is unclear. The aim of this review is to describe the role of exercise on PCSK9-LDLR axis in cardiovascular diseases. Methods This study review 34 previous studies focusing on the effect of exercise on PCSK9 in the human and animal. Results The effects of exercise and lifestyle intervention on hepatic and circulating PCSK9 are controversial. However, exercise con-sistently increases hepatic LDLR, and inhibits atherosclerosis via suppression of PCSK9 and LOX-1 in atherosclerotic region. Conclusions Even though experimental data are still very limited, exercise training can improves blood LDL-C via inhibition of PCSK9 and enhancement of LDLR in liver and vasculature. The study of exercise on PCSK9 are urgently needed.

Keywords

• pcsk9
• ldlr
• exercise
• ldl-c
• atherosclerosis