CHONDROTOXICITY OF FLUOROQUINOLONES IN CHILDREN: YES OR NO?

Abstract

Two groups of children on therapy with monofluoroquinolones were enrolled in this open research trial: 169 patients with cystic fibrosis (exacerbation period) and 55 patients with aplastic anemia (neutropenic phase); age was from 6 months to 16 years. The aim of the study was to compare tolerability (with the focus on arthrotoxicity) of ciprofloxacin, ofloxacin and pefloxacin during intermittent (15-50 mg/kg/day in cystic fibrosis patients) and prolonged continuous therapy (10-15 mg/kg/day in patients with aplastic anemia). Quinolone-induced arthropathy was reported in 7, 6% of all cases, mainly during pefloxacin therapy (31, 8%), and more frequently in patients with aplastic anemia (10, 9% vs. 7, 7%), only in pubertal children, and was fully reversible with no influens on the lineal growth. Following the monofluoroquinolones use, residual joint-related symptoms were not observed because monofluoroquinolones did not achieve chondrotoxic concentrations in cartilaginous structures.

Keywords

• дети
• муковисцидоз
• апластическая анемия
• монофторхинолоны
• артротоксичность
• линейный рост
• морфология хряща
• кумуляция фторхинолонов
• children
• cystic fibrosis
• aplastic avemia
• monofluoroquinolones
• arthrotoxicity
• linear growth
• chondral morphology
• fluoroquinolones accumulation