Prevalence of hyperuricemia in patients with psoriasis vulgaris and influence factors

Abstract

Objective To determine the association between psoriasis vulgaris and hyperuricemia. Methods From September 2021 to May 2022, 100 patients with psoriasis vulgaris were enrolled at our outpatient and inpatient clinics, and 100 age-, sex- and body mass index (BMI) -matched individuals without psoriasis were enrolled at physical examination center. The circulating levels of uric acid were compared between the two groups. Single factor analysis and multi-factor analysis were applied to explore the influencing factors, such as sex, age of onset, disease duration, BMI, smoking and alcohol consumption. Results The prevalence of hyperuricemia in the observation group and the control group was 40.00% and 26.00%, respectively (χ2=4.43, P=0.035). There was no correlation between the PASI and serum uric acid levels (P>0.05). Increased serum uric acid levels in patients with psoriasis vulgaris were associated with gender, duration of disease≥10 years, high BMI, smoking and alcohol consumption (P0.05). Duration of disease, BMI, and alcohol consumption were independent risk factors for concomitant hyperuricemia in patients with psoriasis vulgaris. Conclusions The prevalence of hyperuricaemia is higher in patients with psoriasis vulgaris than in the healthy controls. Gender, disease duration, BMI and history of smoking and alcohol consumption may be associated with hyperuricaemia in patients with psoriasis vulgaris.

Keywords

• psoriasis vulgaris
• hyperuricemia