The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

Kelvin Ka Lok Wu; KeKao Long; Huige Lin; Parco Ming Fai Siu; Ruby Lai Chong Hoo; Dewei Ye; Aimin Xu; Kenneth King Yip Cheng

doi:10.1038/s41467-021-26987-1

Nature Communications (Nov 2021)

The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

Kelvin Ka Lok Wu,
KeKao Long,
Huige Lin,
Parco Ming Fai Siu,
Ruby Lai Chong Hoo,
Dewei Ye,
Aimin Xu,
Kenneth King Yip Cheng

Affiliations

Kelvin Ka Lok Wu: Department of Health Technology and Informatics, The Hong Kong Polytechnic University
KeKao Long: Department of Health Technology and Informatics, The Hong Kong Polytechnic University
Huige Lin: Department of Health Technology and Informatics, The Hong Kong Polytechnic University
Parco Ming Fai Siu: School of Public Health, The University of Hong Kong
Ruby Lai Chong Hoo: The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
Dewei Ye: Guangdong Research Center of Metabolic Diseases of Integrated Western and Chinese Medicine, Guangdong Pharmaceutical University
Aimin Xu: The State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
Kenneth King Yip Cheng: Department of Health Technology and Informatics, The Hong Kong Polytechnic University

DOI: https://doi.org/10.1038/s41467-021-26987-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Inflammasome regulation is not fully understood. Here the authors show that the early endosomal APPL1-Rab5 axis removes damaged mitochondria and then restricts the inflammasome response in macrophages, alleviating the inflammatory diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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