Application of liposomes in drug development – focus on gastroenterological targets

Abstract

Jian-Xin Zhang,1 Kun Wang,1 Zheng-Fa Mao,1 Xin Fan,1 De-Li Jiang,2 Min Chen,2 Lei Cui,1 Kang Sun,1 Sheng-Chun Dang1 1Department of General Surgery, the Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, People's Republic of China; 2School of Chemistry and Chemical Engineering of Jiangsu University, Zhenjiang, Jiangsu Province, People's Republic of China Abstract: Over the past decade, liposomes became a focal point in developing drug delivery systems. New liposomes, with novel lipid molecules or conjugates, and new formulations opened possibilities for safely and efficiently treating many diseases including cancers. New types of liposomes can prolong circulation time or specifically deliver drugs to therapeutic targets. This article concentrates on current developments in liposome based drug delivery systems for treating diseases of the gastrointestinal tract. We will review different types and uses of liposomes in the development of therapeutics for gastrointestinal diseases including inflammatory bowel diseases and colorectal cancer. Keywords: liposome, colorectal cancer, inflammatory bowel disease, drug delivery