Preliminary Study on Raising and Maintaining Clean Mice with Micro-barrier Cages in Conventional Environmental Facilities

Abstract

ObjectiveTo explore the feasibility of breeding cleaning degree mice with micro-barrier cages in conventional environmental facilities.MethodsClean-grade mice were housed and maintained in positive-pressure microbarrier cages in a general environment, during which third-party sampling of the microbial status of the animals in the microbarrier was performed on a quarterly frequency.ResultsFrom June 2020 to July 2022, no microorganisms that must be excluded by the national standard for cleaning degree mice have been detected in two consecutive years.ConclusionMicro-barrier cages can be used to raise and maintain cleaning grade mice in conventional environmental facilities.

Keywords

• micro-barrier cage
• cleaning degree mice
• breeding management