Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration

Atsuya Yaguchi; Mio Oshikawa; Go Watanabe; Hirotsugu Hiramatsu; Noriyuki Uchida; Chikako Hara; Naoko Kaneko; Kazunobu Sawamoto; Takahiro Muraoka; Itsuki Ajioka

doi:10.1038/s41467-021-26896-3

Nature Communications (Nov 2021)

Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration

Atsuya Yaguchi,
Mio Oshikawa,
Go Watanabe,
Hirotsugu Hiramatsu,
Noriyuki Uchida,
Chikako Hara,
Naoko Kaneko,
Kazunobu Sawamoto,
Takahiro Muraoka,
Itsuki Ajioka

Affiliations

Atsuya Yaguchi: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology
Mio Oshikawa: Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
Go Watanabe: Kanagawa Institute of Industrial Science and Technology (KISTEC)
Hirotsugu Hiramatsu: Department of Applied Chemistry, National Yang Ming Chiao Tung University
Noriyuki Uchida: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology
Chikako Hara: Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
Naoko Kaneko: Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences
Kazunobu Sawamoto: Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences
Takahiro Muraoka: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology
Itsuki Ajioka: Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)

DOI: https://doi.org/10.1038/s41467-021-26896-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

The extracellular matrix contributes to tissue regeneration by binding and releasing growth factors. Here the authors present the jigsaw-shaped self-assembling peptide JigSAP as an artificial ECM and show that VEGF-JigSAP has therapeutic effects on the subacute-chronic phase of brain stroke.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal